Myth vs Fact

Scientific Statement

Vitamin D and Disease Prevention

  • Editors
  • Christopher Kovacs, MD

Why is vitamin D important for health?

Vitamin D is a hot topic in the news, thanks to reports claiming its many health benefits. There is controversy, though, over the effects of vitamin D on health other than the bones.

Doctors have long known that vitamin D helps the body absorb calcium and is vital for strong, healthy bones. In fact, a lack of vitamin D can contribute to weak bones in people who have osteoporosis. Severe vitamin D deficiency can cause rickets in children and osteomalacia (“soft” bones) in adults.

Yet, vitamin D is more than a vitamin. It really is a prohormone, a substance that the body converts to a hormone. The skin makes vitamin D after exposure to sunlight. We also absorb vitamin D from certain foods, such as dairy products and certain oily fish, such as salmon, mackerel, and sardines. Vitamin D has its effects by binding to a protein (called the vitamin D receptor). This receptor is present in nearly every cell in the body and affects many different body processes.

The problem is that many people do not make enough vitamin D by exposure to sunlight* or get enough through their diets. They may need supplements to raise their vitamin D level.

Health care providers can measure vitamin D in the body with a blood test. This screening test is for people at risk of vitamin D shortage.

*You should limit your exposure to sunlight to reduce the risk of skin cancer. You should also know that sunscreens interfere with your body’s ability to make vitamin D.

What is the new thinking about vitamin D?

Some studies show that low blood levels of vitamin D may raise the risk of chronic (long-term) health problems, and that getting more vitamin D may lower those disease risks. Health problems that may be linked to low vitamin D include these, among many others:

However, it is not clear if a relationship between non-bone diseases and low vitamin D levels means that low vitamin D causes those diseases. It also is not clear if taking extra vitamin D can protect against chronic diseases.

Therefore, The Endocrine Society asked a panel of experts to prepare a Scientific Statement that would assess scientific evidence about non-skeletal effects of vitamin D. The panel reviewed published studies for some of the health problems linked to low vitamin D. This fact sheet gives an overview of their conclusions, by type of health problem.

Does low vitamin D cause diabetes and obesity?

Studies show that people who have low vitamin D levels are more likely to be obese. However, they do not show that low vitamin D causes obesity. In fact, because vitamin D can become “trapped” in body fat, obesity may cause low vitamin D.

People with low vitamin D, studies show, are likelier to have type 2 diabetes, pre-diabetes, and the metabolic syndrome. (This syndrome is a cluster of risk factors that raise the chance of developing diabetes, heart disease, and stroke.) These diseases are even more likely to affect children and teens with low vitamin D than adults.

Yet, studies have not revealed whether the health problem (such as diabetes) or the low vitamin D came first. Also, most studies have found that vitamin D supplements had no effect on blood sugar. Because these diseases are more likely in people who are obese, it may be the obesity that contributes to vitamin D deficiency.

Can vitamin D supplements prevent heart disease and stroke?

Studies suggest a link between low blood levels of vitamin D and future increased risk of cardiovascular (heart and blood vessel) problems like high blood pressure, heart attack and stroke. Though it is possible that vitamin D supplements will lower the risk of heart disease and stroke over time, there is not enough scientific proof. Too much vitamin D may even raise the risk of heart disease. Until there is proof, experts do not advise taking vitamin D supplements to try to lower your cardiovascular risk.

Does vitamin D prevent muscle weakness and falls?

People whose vitamin D levels are very low often have intense muscle weakness. When they receive vitamin D treatment, the weakness goes away. Yet, most patients also receive calcium with vitamin D treatment. It is therefore possible that vitamin D only indirectly affects muscle function by improving gut absorption of calcium and increasing phosphorus levels in the blood. Phosphorus, another mineral found in bones, is low in vitamin D deficiency.

Some studies point to a link between low vitamin D and falling. Based on the evidence, it is likely that low vitamin D contributes to a modest risk of falls, above all in older adults. Vitamin D supplements are likely to reduce the risk of falls, especially if combined with calcium. They also seem to work best in people whose vitamin D level is insufficient: below 20 nanograms per milliliter (ng/mL). However, the blood level of vitamin D needed by elderly people to prevent falls is not known.

Can vitamin D improve immune function?

New research findings suggest that vitamin D may play a role in immune function—the body’s ability to fight off disease and infections. Yet, researchers have not yet done clinical trials to prove that taking vitamin D supplements could improve immunity. Likewise, there is no good proof that vitamin D supplements could reduce the severity of autoimmune diseases (in which the body comes under attack by its own immune system).

Can vitamin D prevent cancer?

Some studies have linked low vitamin D levels in the blood to a raised risk of cancer and dying of cancer (all types). Other studies have found that the higher the vitamin D intake from supplements, the lower the risk of certain types of cancer. These include

However, we do not yet know if vitamin D supplementation lowers the chance of getting cancer. To date, most studies have not had enough subjects or a long enough follow-up. Also, results have conflicted. Some studies show a benefit from vitamin D, and others find no benefit in reducing cancer risk.

Of concern is some studies suggest that high blood levels of vitamin D (40 ng/mL or above) may raise the risk of some cancers (cancer of the pancreas and esophagus).

What are the experts’ conclusions?

Based on current scientific publications, the panel of experts could not answer the questions here with an absolute “yes” or “no.”

In reviewing published studies, the experts gave the most weight to the “gold standard” for most medical research: randomized clinical trials. In these human studies, researchers randomly assign subjects to one of two or more treatments, and they control for factors that could bias the results. Only randomized clinical trials can find a cause and effect. Observational studies, which simply observe what people are doing and what the outcomes are, often are larger than clinical trials. But, they can show only a relationship between a treatment (or prevention) and an outcome, not cause. For example, observational studies show that more educated people live longer, but that doesn’t mean a better education causes longer life. Instead, the opportunities that come with better education, such as jobs, health care, and income, may be more likely to lead to a longer life.

There were not enough randomized trials on this topic. More randomized studies in large numbers of people are needed before experts can conclude that vitamin D offers preventive and therapeutic benefits for a wide range of chronic non-bone diseases. At least one large randomized clinical trial has already begun to look at whether taking a high daily dose of vitamin D can lower the risk of cancer, heart disease, and stroke. Other studies are looking at whether vitamin D supplementation early in life can prevent type 1 diabetes in children.

Should I take high-dose vitamin D to prevent chronic disease?

The Endocrine Society has advised how much vitamin D people should get to protect their bone health. (See the Hormone Health Network’s Patient Guide to Vitamin D Deficiency.) It does not, however, recommend a high dose of vitamin D to try to prevent non-bone disease, improve quality of life, or extend life. Until more and better scientific data become available, talk to your doctor about whether to test your vitamin D level and how much vitamin D you need.

Resources

The Endocrine Society Scientific Statements