Fact Sheet

Growth Hormone Deficiency in Children

  • Editors
  • Luiz Claudio Castro, MD
    Alan D. Rogol, MD, PhD
    Dorothy I. Shulman, MD

Growth hormone deficiencyWhat is growth hormone deficiency?

Growth hormone deficiency (GHD) is a rare condition in which the body does not make enough growth hormone (GH). GH is made by the pituitary gland, a small organ at the base of the brain.

In children, GH is essential for normal growth, muscle and bone strength, and distribution of body fat. It also helps control glucose (sugar) and lipid (fat) levels in the body. Without enough GH, a child is likely to grow slowly and be much shorter than other children of the same age and gender.

It’s important for parents to know that there are many reasons for slow growth and below-average height in children. At times, slow growth is normal and temporary, such as right before puberty starts. A pediatric endocrinologist (children’s hormone specialist) or primary care doctor can help find out why a child is growing slowly.

What causes GHD?

Some children are born with GHD. Others develop it after birth due to a brain injury, a tumor, or radiation treatment to the head. For some children, doctors can find no cause.

Did you know?

Most children with growth hormone deficiency grow less than two inches (5 centimeters) each year.

How is GHD diagnosed?

Your doctor will review your child’s medical history and growth charts, and look for signs of GHD and other conditions that affect growth. Your doctor may do tests to help find the cause of slow growth. These include

Specific tests for GHD include

How is a child with GHD treated?

Children with GHD receive treatment with daily injections of synthetic (manufactured) human GH, a prescription medicine. The GH, given at home, is injected under the skin. Growth is usually monitored every 3 to 6 months by a pediatric endocrinologist, who will adjust the dose as needed.

The best results occur when GHD is diagnosed and treated early. In some children, GH can lead to four inches (10 centimeters) of growth during the first year of treatment. Others grow less, but usually faster than without treatment. Some children need treatment until adolescence; others need it into adulthood.

Signs of GHD
  • Slowed growth in height in infants, children, or adolescents (teenagers)
  • A young-looking face compared with other children of the same age
  • A chubby body, small hands and feet, and poorly developed muscles
  • Low blood glucose levels (in infants and toddlers with severe GHD)
  • A very small penis (in male newborns with severe GHD)
  • Delayed puberty

What are the side effects of growth hormone therapy?

Mild to moderate side effects are uncommon. They include

Rare but serious side effects include

For most children, the benefits of taking GH outweigh the risks.

What can you do to help your child with GHD?

You can help your child get the best care for GHD by taking these steps:

Questions to ask your doctor