Social awareness and acceptance of transgender individuals has increased dramatically in the past decade. In the United States, an estimated 0.6% of the general population identifies as transgender. A transgender person does not have the same gender identity as the sex assigned to them at birth. The term transgender also includes those who have different gender expressions and behaviors than what society expects for their biologic sex. Transitioning from an assigned sex may or may not involve altering one's body with hormones and/or surgery. Transgender status does not relate to a person’s sexual orientation.
Gender dysphoria is the distress related to sex assigned at birth not matching gender identity. Ways of relieving this distress may vary. For some people, changing the way they dress may be enough. Others may seek hormonal or surgical therapies. Learn more about the hormone therapies in our sections on Masculinizing Hormone Therapies and Feminizing Hormone Therapies. Care for transgender and gender diverse individuals considers behavioral health, physical health and other supportive services.
Please note, none of the medications discussed here are FDA approved for this indication. Please work in close consultation with an endocrinologist when evaluating and using these hormone therapies.